The last proposed mechanism of RBC vasodilation inside the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks to start with researched the nitrite Hb conversation in 1937 which operate was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to sort metHb and NO (Brooks,